Volume 7, Issue 20 (Spring 2024)
J Altern Vet Med 2024, 7(20): 1195-1201 |
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Moghaddasi K, Hesaraki S, Arfaee F, Athari S S. Investigating the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Airway Hyper-Responsiveness of Asthma Mouse Model. J Altern Vet Med 2024; 7 (20) :1195-1201
URL: http://joavm.kazerun.iau.ir/article-1-163-en.html
URL: http://joavm.kazerun.iau.ir/article-1-163-en.html
1- Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran ,SS.Athari@gmail.com
2- Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran ,
Abstract: (140 Views)
Background and aim: Asthma is one of the main lung diseases that is identified by eosinophilic inflammation, mucus secretion, airway hyper-responsiveness (AHR) and airway obstruction. AHR is one of the important action of airways in asthma. Mesenchymal stem cells (MSCs) have regulatory effect on immune response and may be useful to the treatment of asthma. MSCs have low immunogenicity and may be safe in application. Therefore, study effect of mouse bone marrow-mesenchymal stem cells (BM-MSCs) controlling of AHR in asthma model was done.
Materials and Methods: BM-MSCs were isolated and used as treatment in asthmatic male BALB/c mice. To produce asthma animal model, mice were sensitized and challenged with OVA. On days 30 and 40, to measure of AHR, Methacholine (MCh) challenge test was applied to determine the Penh value. Finally, AHR were recorded and analyzed.
Results: Treatment of asthmatic mice with BM-MSCs could control AHR in MCh challenge test and it has significant difference (p<0.05) between days 30 and 40.
Conclusion: BM-MSCs are almost non-immunogenic and can be used to treat asthma and control of AHR. Using of MSCs as anti-asthma treatment presents new and applicable strategy to control of AHR in asthma.
Materials and Methods: BM-MSCs were isolated and used as treatment in asthmatic male BALB/c mice. To produce asthma animal model, mice were sensitized and challenged with OVA. On days 30 and 40, to measure of AHR, Methacholine (MCh) challenge test was applied to determine the Penh value. Finally, AHR were recorded and analyzed.
Results: Treatment of asthmatic mice with BM-MSCs could control AHR in MCh challenge test and it has significant difference (p<0.05) between days 30 and 40.
Conclusion: BM-MSCs are almost non-immunogenic and can be used to treat asthma and control of AHR. Using of MSCs as anti-asthma treatment presents new and applicable strategy to control of AHR in asthma.
Type of Study: Research |
Subject:
Pharmacology and Pathology
Received: 2023/11/4 | Accepted: 2024/04/12 | Published: 2024/05/30
Received: 2023/11/4 | Accepted: 2024/04/12 | Published: 2024/05/30
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