Mendeley  

Zotero  

Cheraghi H, Kianifard D, Tayefi-Nasrabadi H, Parsaeimehr K. Effects of N-carbamylglutamate Administration on Carcass, Liver, and Kidney Weights in Adult Male Rats Exposed to Nicotine. J Altern Vet Med 2023; 6 (19) :1103-1108
URL: http://joavm.kazerun.iau.ir/article-1-153-en.html

Background and Aim: The present study aimed to investigate the effects of N-carbamylglutamate administration on carcass and liver weights in adult male rats exposed to nicotine.
Materials and Methods: Forty adult male rats were randomly divided into four groups of ten rats each. The treatment groups were as follows: 1- Control group, 2- Nicotine group (2 mg/kg/day), 3- N-carbamylglutamate group (500 mg/kg/day administered orally), and 4- Nicotine and N-carbamylglutamate group (2 mg/kg/day nicotine and 500 mg/kg/day N-carbamylglutamate). On the day of euthanasia, the animals were anesthetized with a combination of ketamine and xylazine, and their carcasses were dissected. Internal organs and liver tissue were weighed after separation. Data were analyzed using the GLM procedure of SAS statistical software (version 1/9) in a completely randomized design.
Results: The results demonstrated that N-carbamylglutamate administration increased the body weight of the rats at slaughter. Moreover, co-administration of nicotine and N-carbamylglutamate significantly impacted liver and kidney weights, leading to a decrease in liver weight. Additionally, the weights of both right and left kidneys were reduced in the nicotine and N-carbamylglutamate group compared to the control group.
Conclusion: Long-term nicotine consumption can induce structural alterations in the liver and kidneys. Also, administration of N-carbamylglutamate appears to mitigate the structural and functional changes in liver tissue caused by nicotine exposure in adult rats.