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دوره 7، شماره 20 - ( بهار 1403 )                   جلد 7 شماره 20 صفحات 1211-1202 | برگشت به فهرست نسخه ها


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Habibi G H. Enzybiotics, a Promising Era in Confronting Bacteria in the Poultry Industry. J Altern Vet Med 2024; 7 (20) :1202-1211
URL: http://joavm.kazerun.iau.ir/article-1-147-fa.html
حبیبی غلامحسین. آنزی بیوتیک ها، راه حلی امیدوارکننده در مقابله با باکتری ها در صنعت طیور. مجله طب دامپزشکی جایگزین. 1403; 7 (20) :1202-1211

URL: http://joavm.kazerun.iau.ir/article-1-147-fa.html


گروه علوم بالینی، دانشکده دامپزشکی، واحد کازرون، دانشگاه آزاد اسلامی، کازرون، ایران ، habibigh42@yahoo.com
چکیده:   (156 مشاهده)
از زمان کشف آنتی بیوتیک ها، آنها به طور گسترده ای برای کنترل بیماری ها استفاده شده اند. همچنین مشخص شد که آنتی بیوتیک ها در تقویت رشد در صنعت طیور مفید هستند. با این حال، استفاده بیش از حد و سوء استفاده از آنها منجر به ایجاد مقاومت باکتریایی در برابر آنها شده است. مقاومت به آنتی بیوتیک یک معضل جهانی است که منجر به خسارات بهداشتی و اقتصادی قابل توجهی می شود. مقاومت آنتی بیوتیکی در برابر آنتی بیوتیک های مختلف در عفونت های طیور نیز مشاهده شده است. برای مقابله با بار مقاومت آنتی بیوتیکی، جایگزین های مختلفی برای آنتی بیوتیک ها مورد مطالعه قرار گرفته است. این رویکردهای جایگزین در صنعت طیور نیز مورد توجه قرار گرفته‌اند؛ زیرا عفونت های طیور منجر به زیان اقتصادی چشمگیری می‌شوند و در موارد عفونت‌های مشترک بین انسان و طیور، انتقال عفونت از مرغ سلامت انسان را به مخاطره می اندازد. فاژ درمانی،  استفاده از پروبیوتیک ها و تجویز پپتیدهای ضد میکروبی نمونه هایی از این رویکردهای جایگزین هستند. از دیگر روش های جایگزین آنتی بیوتیک به "آنزی بیوتیک" می توان اشاره کرد. در آنزیبیوتیک ها، پپتیدوگلیکان هیدرولازها (اندولیزین ها) برای تخریب دیواره سلولی باکتری استفاده می شود. این آنزیم ها بیشتر در ژنوم باکتریوفاژها یافت می شوند؛ زیرا باکتریوفاژها باید لایه های پپتیدوگلیکان باکتری ها را هم برای ورود و هم برای خروج از میزبان باکتریایی خود تجزیه کنند. ژنوم باکتری ها همچنین حاوی توالی هایی با خواص پپتیدوگلیکان هیدرولاز است که به رشد و تقسیم باکتری ها کمک می کند. خواص پپتیدوگلیکان هیدرولازهای مختلف برای یافتن انواع قوی تر و کاربردی برای استفاده در آینده مورد مطالعه قرار گرفته است. با توجه به مزایای آنها، اندولیزین ها جایگزین های آنتی بیوتیکی امیدوارکننده ای هستند. در این مقاله به نقش آنزی بیوتیک ها در صنعت طیور خواهیم پرداخت. همچنین، مزایا و محدودیت های تجویز اندولیزین ها مورد بحث قرار می گیرد.
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نوع مطالعه: مروری | موضوع مقاله: بهداشت مواد غذایی
دریافت: 1402/3/25 | پذیرش: 1402/5/28 | انتشار: 1403/3/10

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