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Sanjabi L, Mokhtari M. Investigating the Effect of Gallic Acid on the Level of Liver Enzymes and Some Blood Biochemical Parameters in Male Rats Treated with Escitalopram. J Altern Vet Med 2024; 7 (21) :1212-1225
URL: http://joavm.kazerun.iau.ir/article-1-161-en.html

Background and aim: Escitalopram is a drug that is used for the management and treatment of major depression and generalized anxiety disorders. This study aimed to investigate the protective effects of gallic acid as an antioxidant with different doses in rats treated with escitalopram.
Materials and Methods: In this experimental study, rats were divided into 7 groups including: control group, control group (1 ml of distilled water as drug solvent), experimental groups 1 (10 mg/kg of escitalopram) and 2 (mg 20/kg gallic acid), experimental groups 3, 4 and 5 (first 10 mg/kg escitalopram and then 5, 10 and 20 mg/kg gallic acid respectively) received by gavage for 28 days. At the end of the study, liver enzymes (ALT, AST and GGT) and blood biochemical parameters (ALP, albumin, total protein and total bilirubin) were measured.
Results: Escitalopram administration in experimental group 1 increased the serum levels of ALT, AST, GGT, ALP, albumin, and total bilirubin compared to the control and control groups (P<0.05), but the serum total protein level decreased significantly (P<0.05). The administration of gallic acid in different doses (5, 10 and 20 mg/kg) in rats treated with escitalopram decreased the serum levels of ALT, AST, GGT, ALP, albumin and total bilirubin compared to experimental group 1 (P<0.05), but the total protein serum level showed a significant increase (P<0.05).
Conclusion: Escitalopram in a dose of 10 mg/kg can cause disturbances in liver enzymes and blood biochemical parameters. However, gallic acid as an antioxidant, especially at the maximum dose (20 mg/kg), can improve serum levels of liver profile and blood biochemical parameters in male rats treated with escitalopram.